![]() ![]() Research shows that thiazide-type diuretics (chlorthalidone and indapamide) are superior in preventing cardiovascular disease at a lower cost. Treatment with hydrochlorothiazide as a single agent with a dose of 12.5 mg or 25 mg daily showed no evidence of decreasing morbidity or mortality. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial ALLHAT study recommended thiazide diuretics as the first line of treatment for hypertension unless there are contraindications. Thiazide and thiazide-like diuretics are usually the first-line of treatment for hypertension in JNC8 guidelines, the thiazide diuretics can be used as the first-line treatment for HTN (either alone or in combination with other antihypertensives) in all age groups regardless of race unless the patient has evidence of chronic kidney disease where angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker is indicated. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) ![]()
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